Many different brands and dosage forms of acid are available in the Philippine market. It is important to comprehend the issues encompassing generic medicines versus the use of branded medicines. This attempt the perception and credibility of generic drugs among providers, prescribers and consumers. Taking advantage of this action resulted in increased acceptance of generic medications and educating people of their equal efficacy.
Qualitative and quantitative tests were done on two generic brands of mefenamic acid and an innovator brand to determine equivalence of the former to the latter. The qualitative tests were based on USP requirements and include diameter and thickness measurements, and weight uniformity, friablility, hardness and disintegration. For the quantitative tests, dissolution tests and determination of the mefenamic acid content of the tablets were done.
Qualitatively, results showed that thare are significant differences between the generic brands and Mefenamic acid. Quantitative teste revealed that there are significant differences in the assay values and dissolution profile of the two brands compared to innovator brand. However, the assay value of Brand to Brand C and the dissolution of Brand B to Brand C in phosphate buffer shoe no significant difference. This implies that the two generic brands are not equivalent. Based on the USP requirements, the two generic brand of mefenamic acid passed official in-vitro quality control tests prescribed for the tablets.