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HERDIN Record #: PCHRD08161108082580 Submitted: 16 August 2011 Modified: 16 August 2011

Rapid detection of resistance to isoniazid (INH) in Philippine mycobacterium tuberculosis isolates.

Mirriam Ruth Marzan

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Publication Type
Research Project


General Objective: To develop a method for the rapid determination of resistance to INH exhibited by M. tuberculosis isolates.Specific Objectives:1. To determine which of the existing probes and primers should be used for the amplication and recognition of the Kat G gene of both sensitive and resistant isolates;2. To determine a gold standard for a Kat G. gene of INH sensitive isolates;3. To determine the deviations of Kat G. genes from resistant isolates from this standard;4. To correlate to degree of resistance to INH and the type of mutation observed; and5. To determine if the gene amplification and sequencing techniques developed may be used to determine resistance of sensitivity of isolates in sputum samples.

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