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HERDIN Record #: PCHRDPC000410 Submitted: 16 May 2007 Modified: 04 July 2020

A local prototype pulse-duplicator machine in the Philippine Heart Center: An experimental study.

Cecilio G. Celino,
Christopher C. Cheng,
Avenilo P. Aventura,
Ludgerio D. Torres ,
Florencio G. Castillo ,
Patricia J. Agunod

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A local prototype pulse-duplicator machine was developed at our center with the purpose of testing locally assembled bioprosthetic valves prior to processing and implantation into human subjects METHODS: The valve tester was developed from a single roller pump within a housing that propels priming fluid continuously in a pulsatile flow. The tubings were connected into a plastic cylindrical chamber where the valves were mounted. The cylinder was connected to an afterload tubing which drains the fluid into a reservoir which brings back the fluid to the pump. At a fixed pulsatile rate, the afterload pressures were increased at increments to a range of 0 to 300 mmHg. The tested valves can be directly observed during each cycle for any anatomic or functional defect. Seven biologic valves were individually subjected into the valve tester. At the end of each experiment, anatomic and mechanical defects detected were torn leaflets, loose cusps, asynchronous or poor leaflet motions, or a combination of the above. These valves were considered not suitable for implantation after subjecting them into high pressures CONCLUSIONS: Our local prototype pulse-duplicator machine could serve as an inexpensive valve tester by direct visualization of the valves to screen our locally fabricated bioprosthesis prior to clinical use.

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
July-September 1999
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Box No.44 Fulltext Print Format
Philippine Council for Health Research and Development Fulltext pdf (Request Document)
1. Aymerich, DF , Lovarez, LC . "A manual pulse duplicator to test heart valves before implantation" J Thorac Cardiovasc Surg 66, 25-28, 1973
2. Aventura, AP , Cheng, CC , Celino, CG , Rico, AC . "Long-term clinical performance of the Philippine Heart Center (PHC) bioprosthetic heart valve: results at 17 years" Phil J Thorac Cardiovasc Surg 5(1): 15-20, 1998
3. Aventura, AP , Borromeo, AB , Lomibao, FB . "Clinical experience with mitral valve replacement using the Philippine Heart Center for Asia bioprostheses. First PHCA International Symposium on Valvular Heart Disease. Feb. 12-16, 1985. " Excerpta Medical, Asia Pacific Congress 46,
4. Austin, JW , Hamer, DL . "The heart-lung machine and related technologies of open heart surgery. Phoenix Medical Communication Medical Publishers, Phoenix Arizona" ,