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HERDIN Record #: PCHRD071508020717 Submitted: 14 July 2008

Efficacy of amiodarone with DC cardioversion in chronic atrial fibrillation.

Maria Cristina Tordecilla-Atienza

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Background: With direct cardioversion and pharmacologic antiarrythmic agents, sinus rhythm can be restored at least temporarily in patients with atrial fibrillation. However, there is a small but significant group of patients with chronic atrial fibrillation in whom cardioversion or other anti-arrythmic agents has failed to restore or maintain sinus rhythm. Several studies has supported the effectiveness of amiodarone and electrical treatment (DC Cardioversion) in restoring and maintaining sinus rhythm in patients with chronic atrial fibrillation.

Methods and Results: Studies collected will be appraised using the critical appraisal form for quality assessment of controlled trials. From the studies that will be included, datas that will be extracted are: Population of patients with chronic atrial fibrillation that converted to sinus rhythm (a) after intake of Amiodarone or placebo/other anti-arrythmic drug within 2-4 weeks (loading period) (b) after DC cardioversion in persistent atrial fibrillation despite initial chemical treatment with either Amiodarone or other anti-arrythmic/placebo drug and (c) population of patients who after converting to sinus rhythm has-maintained the rhythm with intake of Amiodarone or placebo/other anti-arrhythmic drug for at least 2 months. Data will be entered in the Cochrane Review Manager Software (Review Manager 4.2.8). Odds Ratio will be calculated. Heterogeneity will be tested using chi-square test (p<0.05).

Conclusion: In patients with chronic atrial fibrillation, Amiodarone increased the success rate of chemical conversion, electrical cardioversion and decreased the occurrence of recurrence. (Author)

Publication Type
Publication Sub Type
Review Articles/Metaanalysis
Philippine Heart Center Journal
Publication Date
April-June 2006


1. To determine the efficacy of Amiodarone in the restoration of sinus rhythm in chronic atrial fibrillation.
2. To assess the effectiveness of pretreating with Amiodarone prior to DC cardioversion in those patients who are non-responding to anti-arrythmic agent or cardioversion alone
3. To determine the efficacy of Amiodarone in maintaining sinus rhythm after cardioversion.

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Philippine Council for Health Research and Development Library Abstract Print Format